Polyphosphate

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Sodium terbium(III) polyphosphate

Single crystals of the title compound, NaTb(PO(3))(4), were obtained by solid-state reaction. This compound belongs to type II of long-chain polyphosphates with the general formula A(I)B(III)(PO(3))(4). It is isotypic with the NaNd(PO(3))(4) and NaEr(PO(3))(4) homologues. The crystal structure is built up of infinite crenelated chains of corner-sharing PO(4) tetra-hedra with a repeating unit of...

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Silver europium(III) polyphosphate

Europium(III) silver polyphosphate, AgEu(PO(3))(4), was prepared by the flux method. The atomic arrangement is built up by infinite (PO(3))(n) chains (periodicity of 4) extending along the c axis. These chains are joined to each other by EuO(8) dodeca-hedra. The Ag(+) cations are located in the voids of this arrangement and are surrounded by five oxygen atoms in a distorted [4+1] coordination.

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Polyphosphate and acidocalcisomes.

Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H(+)-PPase or VP1), the vacuolar proton ATPase (V-H(+)-ATPase) or both, maintain their acidity. A vacuolar transporter chaperone (VTC) complex is involved in the synthesis and translocation of polyP ...

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Polyphosphate enhances fibrin clot structure.

Polyphosphate, a linear polymer of inorganic phosphate, is present in platelet dense granules and is secreted on platelet activation. We recently reported that polyphosphate is a potent hemostatic regulator, serving to activate the contact pathway of blood clotting and accelerate factor V activation. Because polyphosphate did not alter thrombin clotting times, it appeared to exert all its proco...

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The Polyphosphate Kinase Gene ppk2 Is Required for Mycobacterium tuberculosis Inorganic Polyphosphate Regulation and Virulence

The Mycobacterium tuberculosis gene Rv3232c/MT3329 (ppk2) encodes a class II polyphosphate kinase, which hydrolyzes inorganic polyphosphate (poly P) to synthesize GTP. We assessed the role of ppk2 in M. tuberculosis poly P regulation, antibiotic tolerance, and virulence. A ppk2-deficient mutant (ppk2::Tn) and its isogenic wild-type (WT) and complemented (Comp) strains were studied. For each str...

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ژورنال

عنوان ژورنال: Current Opinion in Hematology

سال: 2014

ISSN: 1065-6251

DOI: 10.1097/moh.0000000000000069